Síntese de novos derivados do heterociclo tetrazol para uso em química de coordenação e catálise heterogênea

Abstract

The tetrazole heterocycle has been studied in a more emphatic way during the last two decades because it can be applied in many areas such as agriculture, medicine, biochemistry, photography, explosives, and so on. It is also an important intermediate in the synthesis of high conjugation systems. Many tetrazole derivatives show biological activity since tetrazoles have organic acid force as carboxylic derivatives, being mimetic . They act like excellent nucleophiles as well due to the high negative charge density on nitrogen atoms N1 and N2. That being as such, this work’s objective is to synthesize and characterize new molecules, which are tetrazole derivatives, for subsequent application in two areas of chemistry: coordination chemistry and heterogeneous catalysis. As for the first, two symmetric ligands were prepared, one containing a carboxylic acid function and the second containing its acid mimetic, tetrazole. Both have a flexible chain between the two aromatic units, and will be used for the synthesis of coordination compounds, where the ligand geometry can be correlated to the crystalline structure of the obtained complex. As for the second, a new molecule containing amino and tetrazole functions was synthesized. The amino group will be anchored to a multifunctional polymeric surface, like Arabic gun, and the tetrazole unit will be free to act as a nucleophile in dephosphorylation reaction and will have its catalytic activity evaluated, since the system can act in a similar way to artificial enzymes in organophosphate degradation. All the new molecules were characterized using FTIR, and 1H NMR.