Avaliação da celulose microcristalina para formação de poros em hidroxiapatita

Abstract

The work proposed the synthesis of hydroxyapatite with pores in its physical structure in order to increase the surface area of the material in order to optimize the irrigation of biological fluids after implantation of the material. The strategy is based on the wet synthesis technique with the addition of an organic component in the reaction medium to be removed during the material sintering process. Microcrystalline cellulose was selected for the role of sacrificial reagent due to its fibrous characteristics and accessible degradation temperature for processing without leaving residue. The work evaluated the material through scanning electron microscopy analysis, X-ray diffraction analysis and in-vivo tests with mice together with microtomography analysis. There was success in the synthesis of porous hydroxyapatite, validated by X-ray diffraction analysis, however, with pore diameter values below expectations. Evidence of bone matrix formation was obtained in the region of the implants and there were no signs of rejection and infection in the mice. In comparison with a commercial product, the material synthesized in the work presented satisfactory results.