Degradação da azitromicina através de processos oxidativos avançados

Abstract

Azithromycin is a potent antibiotic and regularly used by peopleand in the treatment of infectious diseases. Often occurs the discharge of tablets that were not used directly to the environment, moreover, there is increased contamination by this drug, through domestic sewage. So objective was to seek a technique to degrade the active ingredient of the drug using Advanced Oxidation Processes, amongs them, the photolytics and Fenton methods. All forms used to generate hydroxyl radicals which interact with the drug and the catalyze reactions.Fenton the methodology is based on the combination of hydrogen peroxide and ferrous sulfate, in quantities of 0.1 ml in the concentrations of 0.01 mol 0.001. L-1 for FeSO4 and 0.003 mol l-1 to H2O2. The photolytic method uses a mercury-vapor lamp (no glass bulb) for generating these oxygen radicals. We used the UV-Vis spectroscopy to monitor the analysis. The method presented photolytic efficiency 95.98% degradation at pH 7.0 in 780 minutes and 89.34% within 20 minutes to pH 4.0. Already in pH 10.0 absorbance was increased immediately on addition of the base, which may have occurred is the formation of degradation products which absorbs the same wavelength, as well as the Fenton technique in which also the increase in absorbance occurred, making it impossible to calculate efficiency. The determination of the kinetics showed as expected for photolysis reactions are typically zero order.