Síntese, caracterização e análise da toxicidade de dois novos compostos da classe triazenos

Abstract

The triazenes compounds are promising compounds in the pharmaceutical industry, in view of which they are antifungal, antibacterial and antineoplastic actions. Therefore, since it is known that cancer is a second-order disease, it no longer exists in Brazil, but also throughout the world, it is necessary that the new treatments be mitigated under the influence of antineoplastics. disease. Anti-inflammatory and arthroplasties were considered important considering the presence of these drugs within the triazenes class. Thus, the work should involve a number of new compounds of the triazenes class: 1- (4-nitrophenyl) -3- (2-benzimidazole) and 1- (4-nitrophenyl) - 3- (2-benzothiazole), as well as such as their characterization by deprotonation test, measurement from the point of view of radiation and ultraviolet-visible and infrared spectroscopy. After the synthesis of the compounds, a toxicity test against Saccharomyces cerevisiae was carried out to determine the LD50 (letal dose 50) so that, if possible, certain toxicity of the compounds synthesized in this work appear to be less toxic than other existing antineoplastic drugs.