Análise do potencial antibacteriano de novos compostos da classe triazenos

Abstract

Cancerous diseases symbolize one of the biggest causes of death in Brazil and in the world, and research to find more efficient antineoplastic treatments has led to the synthesis of many molecules. Moreover, the large increase in bacterial resistance has led to research for new antimicrobial agents. Visibly, the compounds of the triazenes class represent broad pharmacological versatility, exhibiting considerable antitumor and antibacterial activities. In this work two novel compounds of the triazenes class were synthesized: 1,3-bis (2,4-dinitrophenyl) triazene and 1- (4-nitrophenyl) -3- (2,4-dinitrophenyl) ) triazene, characterized by, melting point, deprotonation, by infrared absorption spectroscopy and by electron spectroscopy in the ultraviolet - visible region. Moreover, the antibacterial activity of these two compounds against a gram negative bacterium and a gram positive bacterium were determined, being Escherichia Colli and Staphilococcus aureus, using the method of disc-diffusion in agar that is based on the technique standardized by Clinical and Laboratory Standards Institute (CLSI), approved standard M2-A8 to conduct antimicrobial susceptibility testing by diskdiffusion. The results expressed that these triazenes compounds were not active before these specific bacteria.