Síntese do S-(3,4,5-trimetoxifenil)-3,4,5-trimetoxibenzenosulfonotioato

Abstract

Nowadays note the existence of a change in morbidity and mortality profile of the Brazilian population, where the occurrence of infectious diseases has decreased and putting chronic degenerative diseases such as new center of attention of illness and death issues. Cancer is a chronic degenerative disease that causes many deaths, so it is necessary to search for new therapies and more potent compounds that can assist in chemotherapy treatment. Therefore, it is necessary to develop compounds which possess biological activities, as is the case of the aryl thiosulfonates and thiosulfonates containing sulfur atoms in their structure and have also antitumor activity. The class of aryl thiosulfonates has a wide field of biological activity, but few methods use only thiols as starting material. These compounds have also biological activities such as acaricides, antimicrobials, fungicides and insecticides, which can be an interesting alternative for industry, because synthetic insecticides are highly toxic to humans and the environment. In this present work was synthesized one new aryl thiosulfonate thiols from the coupling. The synthesis of the thiol reactions were performed using as starting material an amine. The compounds obtained were analyzed and all samples were subjected to RMN 1 H 13 C spectroscopy. This paper was obtained in the aryl thiosulfonate S-(3,4,5-trimethoxyphenyl)-3,4,5-trimetoxibenzenosulfonotioato, with a yield of 19.2%, and a novel compound in the literature. Later it will be subjected to biological assays.