Pipeline de ferramentas de Bioinformática para predição de epítopos antigênicos

Abstract

Bioinformatics represents an innovative intersection between computational tools and biological knowledge, playing a fundamental role in scientific research. This study proposes an updated pipeline for predicting antigenic epitopes, aiming to provide a practical guide for researchers. Eight commonly used free bioinformatics tools, along with their specificities, are presented based on literature reviews and statistical analyses of citation frequency in filtered articles from PubMed.. The final pipeline consists of four top-rated tools meeting established criteria: relevance, free access, and context of application in human health. The result is an efficient alternative to reduce time and costs in the development of immunobiologics, standing out for its robustness, including critical decision-making steps and a user-friendly interface that integrates all tools. This work not only provides a comprehensive overview of the current landscape but also identifies future perspectives for the development of vaccines and personalized therapies.