Estudo do potencial antibacteriano de compostos da classe triazeno: uma revisão dos últimos 20 anos

Abstract

Currently, bacterial resistance is one of the most worrying problems for public health, since few antimicrobial agents are effective in the treatment of infections caused by resistant microorganisms, thus limiting the clinical use of antibiotics. However, with the increase in bacterial resistance, there is a great need for researchers to discover new drugs with antibacterial potential. Thus, the triazene class compounds have shown themselves as a promising drug class, with significant antimicrobial and antitumor activity. In this context, the present work carried out a descriptive bibliographic survey of works involving compounds of the triazene class that have antibacterial properties from the last 20 years, prepared from a literature review having as a guiding tool works already published in the databases, BiblioTec, Google Academic, Periodical Capes and Scielo, in the period between 2001 and 2021. The results of the analyzed works showed that most of the triazene compounds showed antibacterial activity, especially those that presented the hydroxyl and carboxyl substituents in their structures. Therefore, with this research it was possible to identify the need to study the triazene compounds as they showed to be a promising antibacterial class according to the works analyzed.