Desenvolvimento de um modelo farmacocinético com fundamentação fisiológica para a aspirina

Abstract

The objective of this work is evaluate if the development of a physiologically based pharmacokinetic model utilizing chemical engineering tools is effective to simulate aspirin and salicylic acid metabolism in the human body. The parameters and mechanisms of absorption process, distribution, metabolism and excretion were obtained from literature. Then, a kinetic model for this substances were created through mass balances, chemical reactions, enzymatic reactions and reactors. The equations obtained were solved in MatLab software. The model equations generated a concentration curve versus time from which the parameters maximum concentration achieved, maximum time, area under the curve, bioavailability and clearance were evaluated. From the analysis of the data obtained, it was concluded that the model was effective to simulate the aspirin and salicylic acid metabolism in the human body, showing that the continuous improvement of models like this could be able to substitute the laboratory tests in animals.