Estudo do comportamento térmico de medicamentos à base de losartana potássica

Abstract

The present research shows a study about the thermal behavior of drugs containing the active ingredient losartan potassium under different compositions, alone or associated with hydrochlorothiazide, being those drugs destined to treatment and control of hypertension, a disease that affects a great parcel of the world’s population, resulting in numerous health issues and consequent risk of death. This study was conducted in the Central de Análises laboratories, located on Pato Branco – PR Campus of the Universidade Tecnológica Federal do Paraná (UTFPR). The sample drugs were obtained commercially, being drug “A” constituted by 50 mg losartan potassium, 12,5 mg hydrochlorothiazide and excipients, drug “B” by 100 mg losartan potassium, 25 mg hydrochlorothiazide and excipients and drug “C” by 50 mg losartan potassium and excipients. Thermal analysis experiments were conducted under different atmosphere and heating rate. Characterization of the studied drugs by infrared absorption spectroscopy was also conducted. The results obtained made it possible to differentiate the drugs containing associated hydrochlorothiazide from the one containing only losartan potassium as an active ingredient by FT-IR, these results also showed no difference on the thermal behavior of the drugs under different heating rates, neither among them despite the different compositions stated above. It was also possible to determine the activation energies of the different compounds studied.