Micropartículas sólidas lipídicas: estudo de variáveis operacionais e encapsulação de vitamina D3

Abstract

Solid lipid microparticles can be readily obtained by the hot dispersion method. A lipid (solid at room temperature) is melted and dispersed in a stabilizer aqueous solution yielding lipid droplets suspended in water. Upon cooling, these droplets form micron-sized particles that can be dried and used as carriers for hydrophobic substances. However, parameters like stirring rate, compounds concentration and the presence of a second lipid influences the final particles morphology and must be carefully evaluated. The objective of this work was to obtain microparticles composed by carnauba wax as solid lipid and use them to encapsulate D3 vitamin. The effect on the average particles size of the following experimental parameters were evaluated: stirring rate, the water:lipid phase mass ratio and the use of medium-chain triglycerides (MCT) as liquid lipid. Results demonstrated that these experimental parameters influenced the average particles size. D3 vitamin was successfully encapsulated in the microparticles with an encapsulation efficiency of 63%.