Estudo dos óleos essenciais de Zinginber officinalis, Murraya koenigii e Coriandrum sativum visando à busca de inibidores de HIV-1 protease

Abstract

Currently, HIV infection is a major problem for the population and ever faster, becomes one of the deadliest viruses in the world. Thus, studies are increasing agents that may interfere with the AIDS virus replication stage. These studies represent an ongoing challenge for the entire scientific community, since HIV can develop very easily, drugs commonly used resistance. Given that the HIV-1 protease plays a key role in the HIV life cycle. This work aimed to study the essential oils from Coriandrum sativum, Zingiber officinalis and Murraya koenigii in order to see if they are possible HIV-1 protease inhibitors. It was found, in most recommended concentration (1000 ppm), that essential oils do not present promising aspartylproteases inhibitory activity. Studies by Nuclear Magnetic Resonance helped confirm that the composition of the oils studied is different from that recorded on the labels of commercial products. Thus, this work contributed to the study of natural products towards other researchers not focus these oils for inhibition of HIV-1 protease, but seek new oils which have potential or even to test the same oils aiming of inhibiting other enzymes in the viral replication cycle, such as reverse transcriptase and HIV integrase.