Estudo da toxicidade de compostos da classe triazenos

Abstract

Cancer is the second most deadly disease worldwide, estimates show the considerable increase in the disease in the coming years, however there is a lot of research that involves new drugs and therapies in order to inhibit or eradicate tumor cells. Among the compounds that have been studied, the triazene class stands out, which have antibacterial, antifungal and antineoplastic properties, some of which are already commercialized, such as Dacabarzina® and Temozolomida ®. Therefore, the present work performed the reproduction of synthesis and toxicity analysis in two triazene compounds 1,3-bis (2,4-dinitrophenyl) triazene and 1 (4- nitrophenyl) -3- (2,4 dinitrophenyl) triazene, with in order to contribute to the development of a possible new drug that is selective to tumor cells. The toxicity analysis was carried out using the in vitro method with bioassay involving the species Lactuca Sativa, against the concentrations of 25, 50 and 100% of both target compounds of analysis. The test was developed using the 850.4200 protocol. Toxicity data were obtained from the determination of lethal toxicity (LD50) and sublethal toxicity (IC50) of both compounds of the triazene class, by means of the germination index and root length of the bioassay seedling. Both compounds of the class triazenes did not obtain lethal toxicity (LD50). For the qualitative sublethal analysis, the compounds showed toxicity for all concentrations, and when compared to each other the symmetrical compound showed greater toxicity in relation to the asymmetric compound.