Um classificador para identificação de mirtrons

Abstract

MicroRNAs is one of the most explored classes of ncRNA as it acts in the cellular control of several biological processes. In order to become mature and qualified to execute their function, the miRNA perform two cleavages in their canonical biogenesis. Some studies in model orga- nisms identified a miRNA subclass, called Mirtrons, originated from a non-canonical biogenesis pathway that omits Drosha cleavage. Thus, the identification of the differences between these two classes is important not only for mirtron prediction algorithms design but to improve the understanding of mirtron functioning too. In this project we developed a computational model dedicated to mirtron prediction and distinction of canonical miRNAs through the extrac- tion and exploration of features identified by the state of art as distinct between these two classes.