Avaliação do efeito da cumarina no tratamento da doença de Parkinson a partir de uma revisão cienciométrica

Abstract

Coumarins or bezopyrones are a class of phenolic compounds derived from cinnamic acid that can be found in various plant species. Given the lack of scientometric studies that relate the use of coumarin for the treatment of Parkinson’s disease (PD), the objective of this work is to carry out a scientometric analysis, showing the scientific trend in the use of this compound for the treatment of PD, since in prolonged use, the conventional drugs have side effects. For this, the research and data collection was carried out in the Web of Science (WoS) database, the results that did not fit the theme were excluded and the data obtained were exported in the BibTex form for the graphics in the Bibliometrix tool. In addition, InOrdinatio was used to prepare the ranking of articles. It was observed that the vast majority of coumarins used for the treatment of PD are synthetic, manipulated around its coumarin ring, showing positive results for the inhibition of monoamine oxidase B, with a reduction of gait disturbances, being that, they were analyzed through in vitro tests, in vivo and in silico.