Desenvolvimento e caracterização do complexo lipossoma/carboximetilcelulose de sódio

Abstract

This study aims to develop a liposomal complex integrated with sodium carboxymethyl cellulose (CMC), exploring the synergies between these two components to optimize drug delivery systems. Liposomes are spherical vesicles primarily composed of lipids, featuring a polar and an apolar group. When in contact with water, they form vesicles that encapsulate polar substances in their aqueous core and apolar substances between the lipid layers. CMC, a polymer derived from cellulose, is notable for its water retention properties and is widely used in medical applications such as dressings and eye drops. The investigation focuses on assessing the encapsulation efficacy and stability of the liposome-CMC complex, using quantitative and qualitative characterization methods. This study also examines the physicochemical interactions between the liposomes and CMC, aiming to understand how these interactions affect the release and bioavailability of the encapsulated drugs. Through advanced analysis techniques such as Dynamic Light Scattering (DLS) and Thermogravimetric Analysis (TGA. This work seeks to establish the foundations for the development of delivery systems that combine therapeutic efficacy with high stability and precision in the release of medical treatments.