Ecotoxicidade crônica do fármaco losartana potássica ao organismo Daphnia magna

Abstract

Losartan potassium (LOS) is the most consumed antihypertensive drug in Brazil. In 2019, more than 150 million units of LOS-based medicines were sold in the country. Among the main environmental discharges through sanitary and sanitary appliances. Thus, they are environmental reports of LOS in the range of ηg L-1 to mg L-1. In this sense, the work aimed to evaluate the eco, LOS, using the possibility of environmental use, evaluating the Daphnia magna organism, as an environmental objective, evaluating the survival rate, the reproduction rate and the beginning of maturation sexual (primiparous). For this purpose, D. magna neonates were exposed for 21 days to three evaluation groups, negative control, LOS solution 0.25 and 2.5 mg L-1. After the period, it was not possible to observe exposure effects (p >0.05) references to survival rate and primiparous. However, when analyzing the size of reproduction, a reduction (p <0.05) (29.11%) was observed in the mean number of offspring in the LOS 2.5 mg L-1 group, when compared to the control group. Through the data obtained, it is observed that the environmental effects of LOS cause adverse effects to the nontarget. As a result, thorough testing is necessary to more conclusively assess conditions of behavior, survival and reproduction of non-target organisms in the face of drugs such as LOS when exposed for long periods.