Síntese, caracterização e separação cromatográfica das quercetinas acetiladas regiosseletivamente

Abstract

In view of the worst phase of human health since the Spanish flu or even AIDS, it can be observed that there are still limits and taboos for science to break, because with the development of vaccines and improvement of molecules, many people have been able to keep a better life quality because of this evolution. Considering that, the organic synthesis that are derivatives and/or provide other molecules cannot be discarded. The fact is that science has been helping mankind and one of the molecules that has been observed a great and growing focus is a variant of the flavonoid group, a group that provides several molecules similar in some aspects but differ in their specific properties. A derivative of this group has come to be known as quercetin, this molecule can interact with the human organism attributing a better quality of life. To improve human health, organic syntheses help the development of new compounds in large scales, thus becoming an irrevocable aspect of science and human evolution. One of these syntheses is called acetylation, a process which allows, in this case, a regioselective exchange, i.e., adding an ethyl in place of the hydrogen of a hydroxyl present in the molecule of origin in a simpler, direct way and with lower costs than there are in several ways already occurred. For this to occur, specific means and reagents characteristic of the reaction medium are necessary, allowing it to be carried out in this way. At first the QU the Ac2O and Py were added to the quercetin, remaining in magnetic stirring. After this step the solution was washed with HCl, NaOH and water, separated through a separating funnel and filtered. After all the synthesis process, the acetylated compound was analysed through the evaluation of gas chromatography coupled to mass spectrometry, thus being able to observe that the technique reached the expected, being a simple and low-cost technique.