Obtenção e caracterização espectroscópica de nanopartículas contendo naringenina

Abstract

Naringenin is a bioactive compound that can be widely found in citrus fruits, and it has a wide variety of health benefits. Therefore, it is present in several scientific research studies, mainly due to its antioxidant properties. However, this compound presents a hydrophobic characteristic that negatively interferes with the absorption and beneficial action of the compound in the body when consumed directly. Thus, this work aims to present an alternative to increase the bioavailability of naringenin. This alternative was the production of nanoparticles containing naringenin, using Poloxamer 407 as an encapsulant through the solid dispersion method. From these produced nanoparticles, analyses were performed using Fourier-transform infrared spectroscopy (FTIR) to verify possible chemical interactions between the reagents and also UV-Vis spectrophotometer analyses to calculate the amount of naringenin that was converted into nanoparticles. The results showed successful encapsulation of naringenin in poloxamer, proving to be an efficient method for possibly solving the challenge presented by naringenin and, therefore, could be applied in medicines and foods, delivering its benefits to the body more efficiently.