Estudo comparativo da luminescência de complexos de Cu(I) com ligantes contendo o heterociclo 1,3,4-Oxadiazol com potencial aplicação em sondas

Abstract

Bioinorganic chemistry is a branch of inorganic chemistry that focuses on studying the role of transition metals in biological systems. The main properties of these metals in living organisms can be modulated by different ligands present in these systems (proteins, sugars, peptides, among others). In order to better understand life at the molecular level, probes that detect, quantify, or image key components involved in biological processes have begun to be studied. Luminescent properties in complexes can come from the ligand and/or the metal. In the case of luminescent ligands, fluorophore groups are used. Metals can also promote the existing luminescence in the ligand; for this purpose, metals with filled d orbitals are preferred to avoid internal extinction processes resulting from d-d transitions. Oxadiazoles are heterocycles containing an oxygen and two nitrogens in a fivemembered ring. The ring confers chemical and thermal stability to the material and intense luminescence. Ligands containing this group have been widely studied due to their antiviral, antitumor, and other applications in biological systems. Therefore, in this work, 4 ligands containing the 1,3,4- oxadiazole group were designed, synthesized, and characterized, all of which were luminescent. Additionally, two Cu(I) complexes were synthesized from Oxa-H and Oxa-Ome ligands, and their structural and photochemical properties were analyzed by 1H NMR and infrared spectroscopy mass spectrometry, UV-Vis spectroscopy, and fluorescence spectroscopy.