Estudo exploratório de modelos para descrição da mecânica pulmonar local utilizando tomografia por impedância elétrica

Abstract

The Pressure-Volume curve is widely applied in the discription of global pulmonary mechanics of the respiratory system, representing great value in mechanic ventilation treatments. However, the use of this resource may be controversial due to pulmonary inhomogeneity caused by possible anatomical, physiological and pathological differences between the various areas of the lungs. Therefore, pulmonary ventilation therapy based on the Global Pressure-Volume curve may cause injuries in specific regions. Based on this problem, previous studies have been conducted to map local pressurevolume curves, quantify pulmonary inhomogeneity and improve the individualization of the parameterization of mechanical ventilation-based treatments. Thus, algorithms were developed for the identification and parameterization of Local Pressure-Volume curves, based on Electrical Impedance Tomography data. The algorithm in question made use of the sigmoidal adjustment technique, already applied the Global Pressure-Volume curves. This project aims to refine the estimates of local respiratory functional parameters and the dynamic model used to assess local pulmonar mechanics. To this end, using a dataset of an animal model (porcine) with induced lung injury, a local Pressure-Volume curve parameterization algorithm was developed using sigmoidal adjustment, sigmoidal without inferior inflection and compressed sigmoid techniques.