Probióticos viabilizados em matriz autopreservante para aplicação cosmética

Abstract

The application of probiotic microorganisms for the maintenance and improvement of human health has been extensively studied. Thus, the mechanisms have been elucidated and its potential to compete with pathogens, have anti-inflammatory action, as well as influence the reconstruction and improvement of the skin barrier has been proven. In addition, the use of the same microorganisms present in the intestinal microbiota in topical application has shown promising results. Studies like this support the use of molecules produced by probiotics as a treatment for a series of skin disorders and are already on the market as commercial formulas. Despite this, the study of the delivery of these bioactive in live vehicles is still being investigated. The objective of this work was to analyze the feasibility of the commercial probiotic microorganism Lactobacillus acidophilus in a cosmetic formulation. The formulation of a minimalist gel was tested combined with different immobilization strategies and comparing different preservatives for inhibition of microbial growth and better adaptation of the probiotic. The best combination was the direct use of a commercial lyophilized strain applied directly to the gel and combined with the preservative’s potassium sorbate and sodium benzoate. A cell count of 6,3.103 UFC /ml was obtained, allowing a minimalist cosmetic formulation capable of keeping reserved cells inside it at room temperature.