Microemulsão como estratégia de liberação de bioativos em formulações tópicas: revisão bibliográfica

Abstract

Drug Delivery systems promote the sustained and targeted release of actives. Microemulsions represent this delivery technology and are characterized by thermal stability, reduced droplet size and ability to solubilize hydrophilic and lipophilic substances. Thus, these systems are considered potential as topical vehicles for the release of bioactive compounds. In this context, this work aimed to carry out a literature review on microemulsions with natural products for dermal and transdermal actives release. The study was conducted through the analysis of recent publications on the subject, evaluating the composition and ways of obtaining microemulsified systems. As well as the different applications and purposes that are proposed. Thus, it was possible to discuss the beneficial properties of the topical administration of microemulsions that use essential oils in the composition for drug solubilization and that incorporate plant extracts for the release of bioactives. With this review, it was possible to verify that microemulsions with natural products are promising for the proposed applications, due to the increase in permeability through the skin barrier and stability of natural substances. As well as by reducing drug toxicity and systemic side effects. Furthermore, they are considered non-cytotoxic and can enhance therapeutic effects.