Desenvolvimento e validação de metodologia farmacêutica do Meloxicam

Abstract

Meloxicam is a medication and antiinflammatorry drug indicated for the treatment of arthritis, osteoarthritis, and neuropathic or musculoskeletal conditions acting to relieve pain in addition to analgesic and antipyretic effects. For the effect drug to be satisfactory, the inputs used in the manufacture must have the expected quality. This work developed and validated an alternative analytical methodology for the quantification of the pharmaceutical ingredient using UV/Vis spectophotometry. The method used the principle of sustainable development, green chemistry, where the performance of the analytical procedures use less aggressive solvents, namely, sodium hydroxideglycine buffer pH 8,6, sodium hydroxideglycine buffer pH 9, the buffer of sodium hydroxideglycine buffer pH 9,4, Sodium hydroxide 0,1 mol L1, and, sodium hydroxide 0,01 mol L1. The use of this principle allows the nongeneration of toxic effluents, and the nongeneration of undesirable gases by volatile solventes, providing environmental and analyst benefits. Solubility tests were carried out, determining the solvent sodium hydroxideglycine pH 9 as the ideal diluent solution for the development of the methodology, with this, the control parameters for validation of the methodology were determined, namely specificity, linearity, range, repeatability, accuracy and robustness, so that it can be put into practice. Validation of the proposed analytical method demonstrated through experimental studies that the developed method is suitable for the intended purpose, ensuring the reliability of the results obtained, whether quantitative or qualitative.