Fatores que influenciam na degradação da matéria-prima sulfametoxazol

Abstract

In the production of sulfamethoxazole + trimethoprim medicines, it was necessary to guarantee the quality of the completely productive process. It had started by analyzes in order to verify the quality of the raw materials that comprise active pharmaceutical inputs and excipients. In this context, spectroscopy in the UV-Visible region has fundamental importance, since it is able to characterize and quantify the potency of active pharmaceutical inputs, by comparison with standards defined in the literature. However, it is a sensitive technique and environmental variations can cause deviations in the results. Therefore, this research presents a practical approach to the response produced by the pharmaceutical active sulfamethoxazole in different experimental conditions in the UV-Visible region. Focusing on the industrial quality control environment, the research evaluates the existence of subtle interferences, which lead to deviations in the results of analyzes necessary to guarantee the quality of a drug production. Because of this study, it is possible to see a panorama of the stability of the molecule throughout the period in which the experiments had carried out, and it emphasizes that there is not degradation of the sulfamethoxazole molecule under the proposed conditions. Moreover, through a preliminary study it proposes the use of an alternative solvent for such analyzes.