IL17A-197G/G (rs22755913) e sucetibilidade a infecção pelo Zika virus em população da região norte e noroeste do Estado do Paraná

Abstract

The Zika virus was first identified in Uganda in 1947 and arrived in Brazil recently in the middle of the year 2014. The infection is characterized as an infectious febrile syndrome, similar to the infection by the Dengue virus, which during the incubation period may lead to the early onset of short-lasting reddish skin rash, sometimes pruriginous. A short time ago alternative hypotheses have suggested the contribution of other factors to the manifestation of ZIKV, among them the genetic constitution of the patients. The present study case control consisted of the investigation of the Association of the IL17A-197 G > A polymorphism, coupled in the IL17A gene, with the acquisition of Zika virus (ZIKV) infection, being carried out with 68 individuals residing in the municipalities belonging to 15 ª Regional and health of Maringá, Paraná. The group of patients consisted of 34 individuals with positive serology for ZIKV and the control group consisted of 34 individuals with negative serology for ZIKV. The DNA of the Leucoplatelet layer (Buffy-coat) of the samples obtained from the patients and the controls was extracted and the PCR-FRLP technique was subsequently used to perform the polymorphic typings. The Association of Genotype IL17A-197 G/G was statistically significant for IL17A and susceptibility to ZIKV infection in the group of patients (0.57 vs 0.40; P = 0.04; OR = 1.92; CI = 0.97 – 3.79). The results obtained in this study indicate a possible participation of the IL17A-197 G > A in the risk of infection by ZIKV in the population of the municipalities of the 15th Regional health of the state of Paraná, if further studies are needed to validate the results here described.