Inferência de gramática formais livres de contexto utilizando computação evolucionária com aplicação em bioinformática

Abstract

Grammatical inference deals with the task of learning a classifier that can recognize a particular pattern in a set of examples. In this work, a new grammatical inference model based on a variant of Genetic Programming is proposed. In this approach, an individual is a list of structured trees representing their productions. Ordinary genetic operators are modified so as to bias the search and two new operators are proposed. The first one, called Incremental Learning, is able to recognize, based on examples, which productions are missing. The second, called Expansion is able to provide the diversity necessary to achieve convergence. In a suite of experiments performed, the proposed model successfully inferred six regular grammars and two context-free grammars: parentheses and palindromes with four letters, including the disjunct one. Results achieved were better than those obtained by recently published algorithms. Nowadays, grammatical inference has been applied to problems of recognition of biological sequences of DNA. In this work, two problems of this class were addressed: recognition of promoters and splice junction detection. In the former, the proposed model obtained results better than other published approaches. In the latter, the proposed model showed promising results. The model was extended to support fuzzy grammars, namely the fuzzy fractional grammars. Furthermore, an appropriate method of estimation of the values of the production's membership function is also proposed. Results obtained in the identification of splice junctions shows the utility of the fuzzy inference model proposed.